Printing PDF books

"I do one of three things, depending on the book:

Print to 2-sided A4 and bind in a lever-arch for storage or dedicated (thinner) binder; this works really well for technical books where I can read a single chapter in a small binder, but page chapters back and forth into my lever-arch collection as required
Print to 2-sided A5 and bind in a dedicated A5 folder (or 6-hole punch for my A5 organiser which comes everywhere with me). Same benefits as above, although you need A5 paper and a printer that handles it
Print to pocketmod format (I use a pstops script in linux). This is brilliant for keeping wallet-sized chapters handy at all times; useful for when you find yourself waiting in a line with time to read but no book.

Also (can you tell I'm an avid reader?) I have a Sony Reader that's always got things on it. Not so good for technical books (PDFs with images/figures/tables are a nightmare), but great for novels. But that's a bit beyond the scope of your question :)"

You can use an imposition software to impose it as a booklet before printing. You will then be able to print two book pages on one A4 side and with duplexing, 4 book pages on one A4 sheet. Try looking for the words, "free imposition booklet" in Google. At some point I found a print driver addon for Mac OS X which did it on the fly.

"i'm sure many of you will find this post right-in-the-bull's-eye.

http://forums.adobe.com/thread/316484?tstart=0

rgrds,
alex"

I googled for glue book binding to find a post I'd read years ago about just painting glue onto a stack of printed pages, and instead found many useful-looking DIY approaches. In particular there was a terrific one on a blog named Talk Like a Duck. He uses an inexpensive purchased program to create properly organized, 4 pages to a sheet, booklets that are then assembled into the book. Very well done presentation.

Your local print shop may be able to do VeloBinding. I've found it to be satisfactory for the type of use you're describing.