"Jeff Atwood has a good article about how to clean up a spyware infection. Following these steps should get you pretty close. Using some of the products recommnded by harrymc will also help you remove this virus.
"This thing about buying a particular new virus checker to cure the Internet Security 2010 virus is exactly what they want you to do, and is a complete waste of money. My system was hit by this horrible virus resulting in the “blue screen of death” and being deprived of access to any controls. What I could do, however, is reboot!
So I rebooted, held down Key F8, and got the boot options.
I chose “System Restore” option and turned the clock back by one week.
Although an error message appeared saying it had failed, it actually hadn’t! When I rebooted, the system was perfect again, and I hadn’t even lost any data – everything was right up to date, and I simply deleted the suspect file the virus came from.