What's the REAL memory requirements of OSX 10.6?

What's the REAL memory requirements of OSX 10.6? I'm running a 3 year old Mac Mini with 2G and Snow Leopard. I'm currently finding that after a couple of days, the machine grinds to a halt with thrashing to VM. I'm running a lot of programs, but I sort of need to run all of them:
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Guest [Entry]

"SL on 2GB should be fine. The problem is most likely Firefox. As much as I love it, the Mac versions have always been less-than-stellar. If you're using a lot of add-ons, it can contribute to the problem. Many are poorly written and leak memory.

If you'd like to pin down what is eating up all the RAM, just open activity monitor and look at ram usage by process."