Which Linux-based file system for very large files?

I was involved in setting up an Thecus N5500 for backups of large files on a network (Copies of virtual machine disks, 150GB+ vmdk files). Initially, I formatted the device as ext3, as it's old, stable, and I've used it before, but I ran into problems with it - files that couldn't be deleted, hanging when trying to access them, etc. Reformatting to XFS, which is built for dealing with large files, completely resolved these issues, so based no my (admittedly small) experience, I'd go with that.