First bootup, do I have to do any BIOS changes?`

"I set up recently my computer with a USB keyboard. When I had to mess with the BIOS I couldn't use it until I enabled USB keyboard compability for DOS (undocumented feature), so I needed a PS/2 keyboard to do that. So I think that this is a good idea to change that flag.

And you should check whether the SATA ports are in IDE compatibility or in AHCI mode. I have seen some BIOS version which default to the former, and I advise you to change it to the proper value. Be careful though, check the drivers of your OS."