Can I use PC3L 12800S RAM in place of PC3 10600S RAM

"Lets breakdown the different elements in the modules description:

PC3L Vs PC3

PC3 is standard voltage (1.50V) where PC3L is low voltage (1.35V) - A system which requires PC3L cannot support PC3 RAM. PC3L RAM will work in a PC3 based system as it will run at the standard voltage and will inter-operate with PC3 RAM within the system.

12800 MB/s (DDR3-1600) Vs 10600 MB/s (DDR3-1333)

This is the speed of the RAM Clearly DDR3-1600 is able to run faster than DDR-1333. But thats only the modules ability not what the system is running its memory bus speed at. Your MacBook was designed for PC3-10600 DDR3 SDRAM, its best to stick with what Apple expects. You can use the faster RAM, but, you really won’t see a sizable difference. So don’t spend extra for the few nano seconds of improvement.

Consider going with more than 8 GB of RAM I would go with 16 GB if you want better performance working on large items or running multiple apps concurrently.

Instead focus on your drive If you haven’t already done it going to a SSHD hybrid drive or better yet a good high speed SSD. Both of these will offer more improvement."

The answer, unfortunately is not definitive.  Usually, yes. But, because of no strict standardization enforcement it may not work. I’d say better to order DDR3 if that is what originally came with your motherboard. I bought 3 PC3L RAM different brands all did not work on my PC3 system.

From the point of the voltage it should work. From the point of frequency there might be a problem. You have to check your CPU. If your computer uses 1'st generation of intel processors, which means it is using HM55 chipset, you computer might not work with PC3L-12800 memory.

"I have changed the RAM of my Toshiba device (Satelite C850-A669)

Processor Intel Core i5 - 2450M @2.5GHZ

Old Ram was

(4GB 2Rx8 PC3-10600S-09-11-F3)DDR3

And the new ram was

First (8GB-PC3L/12800S)DDR3

And the second (8GB-PC3/12800S)DDR3

The problem is that I do not find the same type or frequency

In the market now

The problem occurs in chanting or commenting during videos on YouTube or working on the device for five seconds, and this problem is repeated a lot"