"This is related to the Web Discussions Toolbar that comes with Office 2003 which is an add-in to Internet Explorer. IE is querying your site to see if it supports the extensions required to support this.
The only thing you can do to mitigate the problem is create /MSOffice/cltreq.asp as a zero length file on your server as this will be quicker to serve than a 404 page."
"These requests are generated when someone browses your site with Internet Explorer's Discussion toolbar enabled. You can safely ignore these requests.